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The Theory of Protomorpholgy

In his book, "The Theory of Protomorpholgy", Dr. Royal Lee discusses how he pioneered a unique method of deriving extracts from the "cell determinants" of specific organs and glands for clinical use. Dr. Lee described in detail what these extracts contained and how they functioned in regard to cell regulation, maintenance, and interaction with tissue antibodies. It is clear both from the description of the extraction process and clinical use that these extracts differ from what is commonly referred to as "protomorphogens." Rather, Protomorphogen? is the trademark owned and used by Standard Process Inc., as a brand name assigned to these uniquely derived extracts.

The protomorphogen is the fundamental building block of cell life. It is not DNA or RNA. Nor is it, in its simplest state, a protein or nucleoprotein. It is a "template" or spatial pattern that determines the production of nucleoproteins or other proteins. This primary unit is CELL SPECIFIC, NOT SPECIES SPECIFIC. This is significant. For example, liver protomorphogen is specific as a pattern for liver cell activity; a protomorphogen, properly extracted, is the SAME throughout all mammalian species. Because it is a mineral substrate, it is, for all practical purposes, indestructible.

What does this mean clinically? The practitioner can use horse protomorphogen as well as cow (bovine) protomorphogen just as effectively.

Or, put in more technical terms, this mineral skeleton forms the framework onto which the chromosome (a linear thread in nucleus of cell that contains the DNA) is then constructed. It is believed that this mineral skeleton, along with its associated nucleoproteins forms the shortest unit of the chromosome. This unit, the cell determinant, is easily polymerized to form organized groups of cell determinants that in turn form the gene, and genes then form the chromosome. The basic structure of the cell determinants is predicated on the specific chemical affinities of the mineral components. Dr. Lee believed that the influence of the cell determinant is due, in large part, to the organized groups of mineral links that serve both as a template and a catalyst to initiate the formation of specific protein molecules. At its most basic level, the attached nucleoprotein moiety (one of two equal parts) is simply attracted and bound due to this chemical affinity of the mineral skeleton. It follows then that the individual genetic pattern is actively formed over this basic framework.

While in the cell determinant state, there appears to be an affinity for lipid substances and a high degree of absorption onto connective tissue. It has been demonstrated that when cell determinant levels are low, cell division decreases. In similar fashion, when higher concentrations are present, cell division is inhibited. These studies show that stimulation is exerted by both homologous (similar in structure and origin but not necessarily in function) and heterologous (cell tissue not normal to the part) cell determinants, while inhibition is exhibited by homologous cell determinants. It is critical to note that this stimulation effect is specifically related to normal cellular growth and not the stimulation of abnormal cell patterns.

It also appears that cell determinants can group to form cell-mediated growth factors. There are a number of cell-mediated growth factor cycles. These include the determinant cycle, which is specifically concerned with the organization of cell morphology (the form and structure of an organism or any of its parts) and metabolic cycle, which is related to cellular energy mechanisms.

At mitosis, the chromosome discharges a significant amount of chromatin into the cytoplasm. This organizes the morphology of the cell cytoplasm. The metabolic cycle may be an augmented manifestation of the determinant cycle. It is interesting to note that synthesis and excretion of cell determinants is a dynamic process and appears to occur independently of the determinant cycle, since extracellular cell determinants continue to accumulate even after cell division ceases.

Cell determinants are found intact through the body and play a role in cell growth and regulation. Proper ratios of intracellular and extracellular cell determinants are critical for optimal cellular health. It appears that poor cellular function and abnormal cellular growth may have their roots in abnormalities of the cell determinant cycles. Based on this hypothesis, adding Protomorphogen? brand extracts has been shown to help maintain cellular health. This effect is believed to be the result of keeping the cellular process in proper balance. In an atmosphere of appropriate cellular balance, maintenance and normalization of the cell cycle can occur; especially in the presence of suitable, biochemical supportive nutrients known to have significant influence upon the organ in question, for example, vitamin A on the eyes.

The use of Protomorphogen? brand extracts can aid in maintaining normal cellular metabolism and cell cycling. This is an important feature that should not be overlooked and is perhaps one of the most important aspects for using Protomorphogen? brand extracts in the clinical setting. Of equal importance, it is essential to consistently provide proper nutritional synergists for cellular support. This will improve the efficacy of the clinical application of Protomorphogen? brand extracts.

The Use of Protomorphogens in the Nutritional Therapy

If the theory of protomorpholgy was Dr. Lee's greatest intellectual achievement, then his greatest engineering achievement was in the development and perfection of the process of extracting the protomorphogen and making it available in tablet form. He provided the PMG's for 23 cell types, and thus opened a vast universe of therapeutic tools for the practitioner and patient. In essence, Dr. Lee gave us everything we need to assist cases in which cell growth and/or repair is a factor.

There are two broad categories of cases that can benefit for PMG support. The first is one in which there is or appears to be an actual genetic defect or limitation that precludes normal cell function or growth and the other is what is commonly referred to as "autoimmune disease". The amazing thing about Dr. Lee's work is that he so clearly understood the factors that lead to these "modern" problems and had equally as clearly worked out potential solutions by creating the PMGs. Yet he did this long before aberrant immune response ("auto-immune") was even understood or accepted. Dr. Lee's theory was so far ahead of "current thinking", that he was dismissed as being a quack and was never given serious consideration, except by those practitioners who already knew him and his previous work with whole food supplements. In truth, the practical and incredibly powerful therapeutic application of the protomorpholgy theory was ahead of his time, perhaps by a century or more! The amazing thing about Dr. Lee's work is that he so clearly understood the factors that lead to these "modern" problems and had equally as clearly worked out potential solutions by creating the PMGs. Yet he did this long before aberrant immune response ("auto-immune") was even understood or accepted. In truth, the practical and incredibly powerful therapeutic application of the protomorpholgy theory was ahead of his time, perhaps by a century or more!

The use of protomorpholgy is not expensive. It does not and need not interfere with "orthodox care". It can, properly applied, only help and never hurt. The very worst that can happen is nothing, simply nothing. It does require the admission that the body is truly a self-healing organism, and that sometimes just a very few simple things are needed. The key is finding the right things. If a practitioner finds himself in the trap of thinking that "it's all so complicated", he should just ask himself, "How have humans survived thus far?"

The Natural Food Concentrate Philosophy

Dr. Royal Lee insisted that only naturally occurring food sources contain what the human body REQUIRES for proper function. He believed that the only acceptable therapeutic approach was to concentrate whole foods in such a way as to preserve all the known and UNKNOWN factors. This premise is widely unknown today. It is assumed that SCIENCE can determine ALL aspects of human nutrition and EXTRACT the specific nutrients. This is MARKETING HYPE and bears little resemblance to rational thinking. An EXTRACT is always incomplete and though it may well have great short-term use it can never provide more--not in a "natural" sense! What about research? YES!! But let that research lead us to better farming methods to preserve the wondrous bounty that has been provided us. Let this research lead us to healthful aging "naturally"! PROTOMORPHOGENS


Inserted comments made by Dr. Hadley from Taber's Cyclopedic Medical Dictionary to increase understanding of terms.

The hallmark of Standard Process is the glandular supplements, specifically, the PROTOMORPHOGENS (PMG). Many health practitioners note that there is ABSOLUTELY NO SUBSTITUTE for the protomorphogens manufactured by Standard Process. The publication Protomorphology? The Principles Of Cell Auto-Regulation was presented by Royal Lee and William Hanson in 1947. The two primary factors in the theory are that through alimentary (digestive tract) ingestion.

...Increased amounts of protomorphogen are supplied thereby assisting in a speedier recovery of tissue. ...Increased protomorphogen material acts to speed elimination of increased Natural Tissue Antibodies (NTA) in the blood. (Antibody ? complex glycoproteins produced by B lymphocytes in response to the presence of an antigen. Antibodies, all of which are immunoglobulins, may combine with specific antigens to destroy or control them, providing protection against most common infections. Antigen ? A protein marker on the surface of cells that identifies the cell as ?self? or ?non-self?; identifies the type of cell, e.g., skin, kidney; stimulates the production of antibodies, q.v., by B lymphocytes that will neutralize or destroy to cell if necessary.)

Although the complete text and theory is complex, the empirical evidence of protomorphogen efficacy remains unquestionable. THEY WORK!! The following is a portion of a concise and condensed explanation of how protomorphogens work described by Dr. Royal Lee in 1956.

A protomorphogen (PMG) is that component of the cell chromosome that is responsible for morphogenic (forming of body and organs) determination of cell characteristics. ...It is the smallest unit of the cell blueprint assembly. ...It is the smallest unit of the gene system that guides the cell into it hereditary form as it grows and develops or repairs itself. ...Without sufficient protomorphogens in its chromatin, the cell degenerates, dedifferentiates, becomes senile, and dies.

The protomorphogen level in the cell is regulated by the fact that, while normally more is constantly being created by the cell nucleus, it is antigenic and promotes the formation of antibodies, which in turn control the levels of extracellular protomorphogen in the blood and lymph.

Cytotrophic (Cystol? and Protomorphogen?) Extracts are manufactured under US Patent Number 2,374,219 which states the ?purpose of this patent is to provide an improved method of producing a sterilized dry substance from a juice.? This sterilization takes place below pasteurization temperatures of a juice, thus the synergistic agents, such as amino acids and enzymes are not destroyed. Cytotrophic Extracts are not drugs. They are composed of the mineral fractions of animal tissue which is found associated in the protein molecule. Nutritionally this would be considered in the category of meat extracts. Since hormones are not contained in these products, there are no contraindications as to their use, therefore, they are sold as experimental food preparations. Naturally, no food products are subject to, or restricted by the Experimental Drug Law.

It may be assumed that the specific growth factors (the cellular blueprints known as protomorphogen (PMG) that are constantly being secreted by each cell into it surrounding fluids) are prevented from traveling very far by the influence of specific antibodies, known as Natural Tissue Antibodies (NTA). They must be destroyed, if allowed to build up in any concentration; they would promote cell growth and mitosis (type of cell division). Only if any specific organ becomes subject to overwork and consequent inflammation in some degree does this&occur. A kidney doubles in size in six months after its partner has been removed. Muscles grow if sufficient demand is made on their ability.

Where disease has damaged an organ, such as tuberculosis in the case of the lungs, or where the heart has hypertrophied by overwork, the ingestion of heart or lung PMG, as the case may be, may at first create adverse reactions of a toxic nature (malaise, tiredness), apparently by reason of the immediate protolytic destruction of the ingested PMG by antibodies in the blood stream, that are present in higher amounts than normal, by reason of the long-standing inflammation of the specific organ.

But cardiographic recording have shown that within a few minutes after ingestion of the cardiac PMG the heart action changes for the better. It is hard to explain this reaction other than by assuming that the excess heart tissue antibody in the circulating blood has been reduced by combination with the ingested heart PMG. This is probably done without danger of stimulating the formation of more heart tissue antibody, since alimentary ingestion normally does not permit proteins to act as antigens. Parenteral (Denoting any medication route other than the alimentary canal; such as intravenous, subcutaneous, intramuscular, or mucosal) introduction of such materials is another matter.

Other factors that assist in controlling NTA are allantoin (amniotic fluids as an end product of purine metabolism in mammals other than primates), Betaine, (probably by a depolymerizing [the breakdown or splitting of polymer into their basic building blocks or monomer] effect), and the hormones of the gonads, thyroid, thymus, and adrenal. Thymus acts by promoting colloidal dispersion that physiologically opposes cortisone, which flocculates antigen into particulate dimensions that permit their ingestion by phagocytes (and then antibody formation). The thymus during the development age, prevents this and keeps PMG available for growth stimulation and ultimate enzyme digestion and renal elimination.

Thyroid hormone splits PMG off the chromatin reserves of the cell, or from absorbed stores in connective tissue. That is why thyroxin accelerated tadpole metamorphosis. It is also the reason why thyroxin increases the metabolic rate. The released PMG stimulates cell activities. "Promotes Healing Over Time"


Protomorphogens (PMG) are extracts of nucleic acids from the nucleus of the cell. The nucleic acids control the function of the cell. Many doctors and scientists use the terms protomorphogens and glandulars interchangeably. While not strictly accurate, the protomorphogen is a fundamental type of glandular product, and the principal source of the reputation Standard Process has earned over many decades for clinical results.